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Updated: Jan 22, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
An expanding GSK3 network: implications for aging research.
Dylan C Souder1, Rozalyn M Anderson2,3
1Division of Geriatrics, Department of Medicine, SMPH, University of Wisconsin, Madison, WI, 53705, USA.
Glycogen synthase kinase (GSK3) is a key factor in metabolism and growth regulation, influencing how we age. Research suggests GSK3 plays a role in age-related diseases and may be a target for interventions to promote healthy aging.
Area of Science:
- Gerontology and cellular biology
- Metabolic regulation and aging
Background:
- Longevity and healthspan are malleable, influenced by metabolism and growth.
- Glycogen synthase kinase (GSK3) is emerging as a critical factor in cellular adaptation and aging.
Purpose of the Study:
- To explore the role of GSK3 in aging processes.
- To investigate GSK3's involvement in age-related diseases.
- To evaluate GSK3 as a potential therapeutic target for age-related conditions.
Main Methods:
- Review of existing literature on GSK3, metabolism, and aging.
- Analysis of GSK3's function in cellular processes like growth signaling and metabolism.
- Examination of evidence linking GSK3 to age-related diseases.
Main Results:
- GSK3 is implicated in fundamental cellular functions including growth, cell fate, and metabolism.
- Direct evidence links GSK3 to various age-related diseases, irrespective of their specific causes.
- GSK3's role in normative aging suggests its potential impact on age-related vulnerability.
Conclusions:
- GSK3 is a significant factor in aging and age-related disease.
- Targeting GSK3 may offer a strategy to counteract age-related disease vulnerability and promote healthy aging.
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