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Maintenance Therapy in Metastatic Solid Tumors: Innovative Strategy or Simple Second-line Treatment?
Elise Rowinski1, Pierre Fournel1, Emilie Bernichon1
1Departments of Medical Oncology.
American Journal of Clinical Oncology
|July 18, 2019
Summary
This review clarifies maintenance therapy in oncology, distinguishing continuation and switch strategies for metastatic diseases. It addresses pending issues like duration, cost, and tolerability for improved cancer care.
Area of Science:
- Oncology
- Clinical Pharmacology
Background:
- Metastatic disease management requires balancing treatment efficacy with patient quality of life.
- Current clinical practice employs stop-and-go or maintenance strategies.
Purpose of the Study:
- To define and describe maintenance therapy strategies in oncology.
- To discuss current indications and future challenges of maintenance therapy.
Main Methods:
- Review of existing literature on maintenance therapy in solid tumors.
- Analysis of continuation maintenance and switch maintenance approaches.
Main Results:
- Two primary maintenance strategies exist: continuation and switch.
- Several drugs are approved for maintenance therapy in solid tumors.
- Unresolved questions include optimal duration, cost, and tolerability.
Conclusions:
- Maintenance therapy is a key strategy in oncology, with ongoing research.
- Further investigation is needed to address pending challenges for optimal patient outcomes.
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