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Updated: Jan 22, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Assessment of myocardial viability by myocardial contrast echocardiography: current perspectives
Jiwan Pradhan1, Roxy Senior1,2,3
1The Northwick Park Hospital, Harrow.
Insights
Myocardial contrast echocardiography (MCE) effectively assesses myocardial viability by evaluating microvascular integrity. Current guidelines support its routine use, offering a radiation-free, real-time bedside tool for critical cardiac conditions.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Myocardial viability assessment is crucial in ischemic cardiomyopathy and post-myocardial infarction with left ventricular dysfunction.
- Myocardial contrast echocardiography (MCE) is recommended by current guidelines for assessing myocardial viability.
Purpose of the Study:
- To review the utility of MCE in assessing myocardial viability.
- To highlight MCE's role in evaluating microvascular integrity and coronary flow reserve.
- To discuss MCE's application in detecting no-reflow post-myocardial infarction.
Main Methods:
- Review of current literature and guidelines on MCE for myocardial viability.
- Discussion of MCE's ability to assess microvasculature integrity in real-time.
- Comparison of MCE with other imaging modalities like SPECT, cardiac MRI, and PET.
Main Results:
- MCE provides real-time, bedside assessment of myocardial viability without ionizing radiation.
- MCE demonstrates comparable sensitivity and specificity to SPECT, cardiac MRI, and PET for viability detection.
- Newer evidence supports MCE-derived coronary flow reserve and its use in detecting no-reflow post-MI.
Conclusions:
- Ample evidence supports the routine use of MCE for myocardial viability detection as per current guidelines.
- MCE is a valuable, non-invasive tool for assessing myocardial viability in specific clinical scenarios.
- MCE offers a rapid and accessible method for bedside evaluation of myocardial health.
Purpose Of Review:
The current guidelines recommend the use of myocardial contrast echocardiography (MCE) to assess myocardial viability. There are two clinical scenarios where detection of myocardial viability has clinical significance: in ischemic cardiomyopathy and following acute myocardial infarction with significant left ventricular dysfunction. Myocardial contrast echocardiography (MCE), which utilizes microbubbles can assess the integrity of the microvasculature, which sustains myocardial viability in real time and can hence rapidly provide information on myocardial viability at the bedside without ionizing radiation.
Recent Findings:
We discuss the value of MCE to predict myocardial viability through the detection of the integrity of myocardial microvasculature, the newer evidences behind the MCE-derived coronary flow reserve and use of MCE postmyocardial infarction to detect no-reflow. Newer studies have also demonstrated the comparable sensitivities and specificities of MCE to single photon-emission computed tomography (SPECT), cardiac myocardial resonance imaging and PET for the detection of myocardial viability.
Summary:
Ample evidence now exist that supports the routine use of MCE for the detection of viability as laid down in recent guidelines.
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