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Updated: Jan 22, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Changing Indications for Corneal Transplantations in Southern Taiwan From 2008 to 2018
Tso-Wen Wang1, Ying-Chen Chi, Pying-Sing Hsu
1Department of Ophthalmology (T.-W.W., P.-S.H., N.-W.K., J.-L.C.), Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Healthcare Information and Management (Y.-C.C.), Ming Chuan University, Taoyuan, Taiwan; Department of Optometry (J.-L.C.), Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan; School of Medicine, National Defense Medical Center (J.-L.C.), Taipei, Taiwan; and School of Medicine (J.-L.C.), National Yang-Ming University, Taipei, Taiwan.
Objectives:
To investigate the changing indications for corneal transplantations in southern Taiwan from 2008 to 2018 and compare the results with those of other previous studies.
Methods:
We retrospectively reviewed the records of patients who underwent corneal transplantations from January 2008 to December 2018 at Kaohsiung Veterans General Hospital. The patients' age, sex, indication for corneal transplantation, and the surgical technique were recorded and analyzed.
Results:
In total, 336 patients (421 eyes) were included in our study from January 1, 2008, to December 31, 2018. The mean age was 63.6±15.3 years; 371 penetrating keratoplasty (88.1%), 35 deep anterior lamellar keratoplasty (8.3%), and 15 Descemet-stripping automated endothelial keratoplasty (3.6%) were performed. The leading indication for corneal transplantation was regraft (n=103, 24.5%), followed by bullous keratopathy (n=82, 19.5%), corneal scar and opacity (n=79, 18.8%), keratitis (n=59, 14.0%), corneal dystrophy (n=58, 13.8%), other indications (n=26, 6.2%), and keratoconus (n=14, 3.3%).
Conclusion:
The indications for corneal transplantations changed with time in Taiwan. Regraft was the leading indication, but there was a decreasing trend over time. The proportion of bullous keratopathy increased significantly over the past decade and is the second most common indication, similar to the most developed countries. Both corneal scar and opacity, and keratitis showed a decreasing trend of occurrence compared with a previous study in Taiwan. The proportion of keratoconus remained low, making it the least common indication for corneal transplantation.
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