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Related Concept Videos

Integrins01:10

Integrins

5.3K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
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Activation of Integrins01:15

Activation of Integrins

5.0K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
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Adhesion01:14

Adhesion

43.6K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
43.6K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.3K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.2K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.2K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

9.1K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Related Experiment Video

Updated: Jan 22, 2026

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

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Cell Adhesion by Integrins.

Michael Bachmann1, Sampo Kukkurainen1, Vesa P Hytönen1

  • 1Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire , Geneva , Switzerland ; and Faculty of Medicine and Health Technology, Tampere University, and Fimlab Laboratories , Tampere , Finland.

Physiological Reviews
|July 18, 2019
PubMed
Summary
This summary is machine-generated.

Integrins are cell surface receptors crucial for cell adhesion and intracellular signaling. This review explores their diverse roles in physiology and pathology, highlighting their importance in mechanobiology.

Keywords:
cell adhesionfibronectinintegrinmechanosensingtalin

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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
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Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

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Last Updated: Jan 22, 2026

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
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Area of Science:

  • Cell Biology
  • Biochemistry
  • Mechanobiology

Background:

  • Integrins are vital cell surface receptors mediating cell-extracellular matrix mechanical connections.
  • These receptors play critical roles in intracellular signaling pathways.
  • Integrins are implicated in numerous physiological and pathological processes.

Purpose of the Study:

  • To provide a comprehensive overview of integrin receptors.
  • To discuss historical, structural, and physiological aspects of integrins.
  • To contextualize integrin functions within the field of mechanobiology.

Main Methods:

  • Literature review
  • Synthesis of existing research
  • Exploration of historical data

Main Results:

  • Integrins facilitate cell anchorage and transmit signals.
  • Their functions extend to diverse physiological and pathological conditions.
  • Mechanobiology offers a new framework for understanding integrin roles.

Conclusions:

  • Integrins are multifunctional receptors with broad biological significance.
  • Further research into integrins is essential for advancing cell biology and medicine.
  • The study of integrins promises continued discoveries for future researchers.