The regulation of Langerhans cell T6, DR and DQ antigen expression: an hypothesis

A hypothetical model of the maturation pathway of Langerhans cells (LC) within an epithelial environment is presented. This model is based on in vitro studies using human gingival organ culture. In this model, T6 (CD1) antigen is induced on a T6(-) intraepithelial population by Interleukin-1 secreted by epithelial cells. This process is abrogated by a locally produced Interleukin-1 inhibitor, ILS. These T6(+) LC then express first HLA-DR and subsequently HLA-DQ surface antigens under the influence of either lipopolysaccharide or gamma interferon. The induction of these Class II antigens on LC is inhibited by prostaglandin E2. It is postulated that these Class II antigen positive LC are then available to function as antigen presenting cells. This hypothesis is consistent with in vitro studies and several in vivo observations. The basis of the hypothesis is the demonstration that locally produced factors may exert an influence on LC behaviour within an epithelial environment.