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Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
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An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging.

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Researchers developed a novel fluorescent probe for detecting carbon monoxide (CO) in living systems. This probe utilizes aggregation-induced emission (AIE) for enhanced visualization of CO, overcoming limitations of previous methods.

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Area of Science:

  • Biomedical Engineering
  • Chemical Biology
  • Analytical Chemistry

Background:

  • Carbon monoxide (CO) acts as a crucial gasotransmitter regulating inflammatory processes.
  • Visualizing CO *in situ* is essential for understanding its physiological and pathological roles.
  • Existing fluorescent probes often suffer from aggregation-caused quenching (ACQ), limiting their utility.

Purpose of the Study:

  • To develop a novel fluorescent probe for sensitive and selective *in situ* detection and imaging of CO.
  • To overcome the limitations of ACQ in existing CO probes by employing aggregation-induced emission (AIE).

Main Methods:

  • A reaction-based fluorescent probe, BTCV-CO, was synthesized using a two-step method with high yield.
  • The probe exhibits aggregation-induced emission (AIE) characteristics for CO detection.
  • Ratiometric detection was employed to enhance accuracy and stability.

Main Results:

  • The BTCV-CO probe demonstrated excellent stability and superior selectivity for CO detection.
  • High sensitivity was achieved, with a low detection limit of 30.8 nM.
  • The probe enabled real-time visualization of CO in living systems.

Conclusions:

  • The developed BTCV-CO probe is a highly sensitive and selective tool for CO detection and imaging.
  • Its AIE properties offer advantages over traditional ACQ-based probes.
  • This probe provides a facile and effective method for *in situ* CO visualization in biological research.