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Updated: Jan 22, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control
Domenico Giordano1, Valeria Cernaro2, Mariagrazia Scilipoti3
1Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Purpose:
To evaluate the relation between CD34+ cells count in maternal blood and potential development of fetal congenital renal abnormalities.
Materials And Methods:
We enrolled 16 women that gave birth to newborns carrying congenital renal malformations over a 3-year period and 48 women with uncomplicated pregnancies (controls) in a 1:3 ratio (three controls per case).
Results:
CD34+ cells in the maternal peripheral blood were significantly lower in the group of women who gave birth to newborns carrying congenital renal malformations compared to the controls (p < .0001).
Conclusions:
CD34+ cells in maternal blood could be validated as a potential marker to predict the development of possible kidney malformations.
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