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Updated: Jan 22, 2026
06:45
Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
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Ascorbic Acid, Thiamine, and Steroids in Septic Shock: Propensity Matched Analysis.
Farid Sadaka1, Justin Grady1, Nikhil Organti1
124116Mercy Hospital St Louis/St. Louis University, St. Louis, MO, USA.
Journal of Intensive Care Medicine
|July 19, 2019
Summary
Intravenous ascorbic acid, thiamine, and steroids (ATS) may benefit septic shock patients. This treatment showed lower intensive care unit mortality and a trend toward reduced hospital mortality.
Area of Science:
- Critical Care Medicine
- Pharmacology
- Biochemistry
Background:
- Septic shock (SS) is a life-threatening condition requiring effective treatment strategies.
- The combination of intravenous ascorbic acid, thiamine, and steroids (ATS) is being investigated for its potential benefits in SS management.
Purpose of the Study:
- To evaluate the efficacy and impact of ATS treatment in patients diagnosed with septic shock.
- To compare outcomes between patients receiving ATS and those not receiving ATS.
Main Methods:
- A retrospective analysis of 62 septic shock patients was conducted.
- Patients received full doses of intravenous ATS (ascorbic acid, hydrocortisone, thiamine).
- Propensity analysis matched patients based on key clinical variables to ensure comparability.
Main Results:
- The ATS group experienced a longer duration of vasopressor use (P = .001).
- No significant differences were observed in renal replacement therapy for acute kidney injury or mechanical ventilation-free days.
- The ATS group showed significantly lower intensive care unit mortality (9.6% vs 42%, P = .004).
Conclusions:
- Intravenous administration of ascorbic acid, thiamine, and hydrocortisone may offer therapeutic benefits for patients with septic shock.
- Further research is warranted to confirm these findings and optimize ATS treatment protocols.
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