Related Experiment Video
Updated: Jan 18, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
[Advances in the regulation mechanism of cholinergic anti-inflammatory pathway on sepsis]
Qingxiang Liu1, Jianfeng Xie, Yi Yang
1Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China. Corresponding author: Yang Yi,
Objective:
Excessive or persistent inflammatory response is an important pathophysiological feature of sepsis, and the tissue damage and organ dysfunction caused by sepsis are related to the prognosis of patients. The cholinergic anti-inflammatory pathway releases acetylcholine (ACh) through the vaginal nerve and acts on the surface of the inflammatory cell α7 nicotine acetylcholine receptor (α7nAChR) to inhibit the production of inflammatory factors, so that the inflammatory response tends to be balanced. This article reviews the composition and effects of cholinergic anti-inflammatory pathways, the mechanism of regulating sepsis and its clinical application, in order to provide a new direction for the treatment of sepsis.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Inflammation
Parasympathetic Signaling
The effects of...
Inflammatory Response I: Vascular and Cellular

