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Apomorphine induces latent rotation in lesioned rats, amphetamine does not
1Department of Psychiatry and Behavioral Sciences - MSI University of Texas Medical School, Houston 77030.
Life Sciences
|January 1, 1988
Summary
Apomorphine (Apo) induced latent circling behavior in rats with nigrostriatal lesions, unlike (+)-amphetamine (Amph), which showed no latent effect. This highlights apomorphine's unique ability to trigger persistent motor responses after initial drug exposure.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Unilateral 6-hydroxydopamine (6HDA) lesions create an imbalance in nigrostriatal dopamine pathways.
- Investigating drug-induced behaviors in lesioned models is crucial for understanding dopamine system function.
Purpose of the Study:
- To compare the efficacy of apomorphine (Apo) and (+)-amphetamine (Amph) in inducing latent rotational behavior.
- To determine if these drugs elicit persistent behavioral changes after initial administration in a rat model.
Main Methods:
- Rats underwent unilateral 6HDA lesions of the nigrostriatal pathway.
- Animals were treated with either apomorphine or (+)-amphetamine.
- Rotational behavior was acutely measured post-drug and assessed for latent effects weeks later.
Main Results:
- Apomorphine acutely induced contralateral rotation and later exhibited latent contralateral circling.
- (+)-amphetamine acutely induced ipsilateral rotation but showed no latent drug effect.
- Significant differences were observed in the long-term behavioral responses to Apo versus Amph.
Conclusions:
- Apomorphine demonstrates a capacity to induce latent behavioral effects in a lesioned dopamine system.
- (+)-amphetamine does not produce similar latent behavioral changes.
- These findings suggest distinct mechanisms of action or recovery following apomorphine and amphetamine treatment in this model.