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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Trained Circulating Monocytes in Atherosclerosis: Ex Vivo Model Approach
Nikita G Nikiforov1,2,3, Reinhard Wetzker4, Marina V Kubekina2
1National Medical Research Center of Cardiology, Institute of Experimental Cardiology, Moscow, Russia.
Frontiers in Pharmacology
|July 19, 2019
Summary
Monocyte training, an enhanced immune response, may link to atherosclerosis progression. Suppressing trained immunity in experiments offers a new avenue for developing anti-atherogenic drugs.
Area of Science:
- Immunology
- Cardiovascular Research
- Pathogenesis of Atherosclerosis
Background:
- Inflammation is central to atherosclerosis development.
- Circulating monocyte activation states may precede local plaque events.
- Monocyte tolerance and training represent distinct immune response patterns.
Purpose of the Study:
- To investigate the relationship between monocyte training and atherosclerosis.
- To explore the potential of trained immunity suppression as an anti-atherogenic strategy.
Main Methods:
- Analysis of monocyte/macrophage function from atherosclerosis patients.
- Ex vivo experiments assessing monocyte training suppression.
Main Results:
- Data suggest a correlation between monocyte training and atherosclerosis severity.
- Suppression of trained immunity ex vivo was observed.
Conclusions:
- Monocyte training may play a role in atherosclerosis progression.
- Targeting trained immunity suppression is a promising approach for anti-atherogenic drug discovery.
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