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Updated: Jan 22, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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The Relationship between Infant Colic and Migraine as well as Tension-Type Headache: A Meta-Analysis

Dongli Zhang1, Yuan Zhang1, Yan Sang1

  • 1Second Ward of Department of Neurology, XuZhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Pain Research & Management
|July 19, 2019
PubMed

Insights

Infant colic history is more common in migraine patients but not associated with tension-type headache (TTH). This meta-analysis clarifies the link between early childhood colic and primary headache disorders in pediatrics.

Area of Science:

  • Neurology
  • Pediatrics
  • Gastroenterology

Background:

  • Infant colic is a common, benign condition in early infancy.
  • Migraine and tension-type headache (TTH) are prevalent primary headache disorders in children.
  • Previous research explored the link between infant colic and these pediatric headache types.

Purpose of the Study:

  • To conduct a meta-analysis assessing the relationship between infant colic and migraine.
  • To evaluate the association between infant colic and TTH in pediatric populations.

Main Methods:

  • Searched PubMed, Web of Science, and Cochrane Library for relevant studies up to August 2018.
  • Extracted data from 7 included studies using RevMan 5.2 software.
  • Calculated odds ratios (ORs) with 95% confidence intervals (CIs) to determine associations.

Main Results:

  • A higher incidence of infant colic was observed in migraine patients compared to controls (OR: 2.51, 95% CI: 1.32-4.77).
  • A significant inverse association was found between infant colic and TTH (OR: 0.33, 95% CI: 0.13-0.86).
  • No significant association was found between TTH and controls (OR: 1.17, 95% CI: 0.73-1.89).

Conclusions:

  • Migraine is associated with an increased incidence of infantile colic history.
  • TTH incidence is not significantly relevant to the incidence of infantile colic history.
Abstract

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