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Related Experiment Video

Updated: Jan 22, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

Fibrillary Glomerulonephritis: An Update.

Jordan L Rosenstock¹, Glen S Markowitz²

¹Division of Nephrology, Lenox Hill Hospital, Hofstra Northwell School of Medicine, New York, New York, USA.

Kidney International Reports

|July 19, 2019

Summary

This summary is machine-generated.

Fibrillary glomerulonephritis (FGN) is a rare kidney disease. DNAJB9 protein is a key component of FGN fibrils, enabling diagnosis without electron microscopy.

Keywords:

DNAJB9 fibrillary glomerulonephritis

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Published on: February 19, 2021

Area of Science:

Nephrology
Pathology
Molecular Biology

Background:

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease.
Characterized by randomly oriented fibrillar deposits (mean diameter 20 nm).
Immunofluorescence shows IgG, C3, and light chain deposits, suggesting immune complex involvement.

Purpose of the Study:

To highlight the discovery of DNAJB9 as a major fibril component in FGN.
To emphasize the diagnostic utility of DNAJB9 immunohistochemistry.
To underscore the poor prognosis and limited treatment options for FGN.

Main Methods:

Immunofluorescence (IF) staining for IgG, C3, kappa, and lambda light chains.
Immunohistochemical staining for DNAJB9.
Analysis of fibrillar deposit composition and ultrastructure.

Main Results:

Fibrillar deposits in FGN are composed of DNAJB9.
DNAJB9 immunohistochemistry facilitates FGN diagnosis, obviating the need for electron microscopy.
FGN is associated with a poor prognosis, limited therapeutic strategies, and frequent transplant recurrence.

Conclusions:

DNAJB9 is a crucial diagnostic marker for FGN.
Accurate diagnosis of FGN is essential due to its poor prognosis.
Further research is needed to develop effective treatments for FGN.