A carbon paste electrode modified with Al₂O₃-supported palladium nanoparticles for simultaneous voltammetric...

The authors have modified a carbon paste electrode with Al₂O₃-supported palladium nanoparticles (PdNP@Al₂O₃) to obtain a sensor for simultaneous voltammetric determination of melatonin (MT), dopamine (DA) and acetaminophen (AC). The PdNP@Al₂O₃ was characterized by scanning electron microscopy and energy-dispersive X-ray spectra. The sensor can detect DA, AC, MT and their mixtures by giving distinct signals at working voltages of typically 236, 480 and 650 mV (vs. Ag/AgCl), respectively. Differential pulse voltammetric peak currents of DA, AC and MT increase linearly in the 50 nmol L^-1 - 1.45 mmol L^-1, 40 nmol L^-1 -1.4 mmol L^-1, and 6.0 nmol L^-1 - 1.4 mmol L^-1 concentration ranges. The limits of detection are 36.5 nmol L^-1 for DA, 36.5 nmol L^-1 for AC, and 21.6 nmol L^-1 for MT. The sensor was successfully used to detect the analytes in (spiked) human serum and drug samples. Graphical abstract Schematic presentation of Al2O3-supported palladium nanoparticles (PdNP@Al2O3) for modification of a carbon paste electrode (CPE) to develop a voltammetric sensor for the simultaneous determination of dopamine (DA), acetaminophen (AC) and melatonin (MT).