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Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An
Bernardo Lembo Conde de Paiva1,2, Edson Bor-Seng-Shu3,4, Eliezer Silva5
1Neurology Department, School of Medicine, University of São Paulo, Avenida Moema, 170, Cj. 83 - Moema, São Paulo, SP, CEP: 04077-020, Brazil. bernardo@floecorp.com.
Neurocritical Care
|July 19, 2019
Summary
A novel nasopharyngeal catheter effectively cooled the brain in pigs, significantly reducing brain temperature without systemic complications. This selective brain cooling method offers a safer alternative to whole-body cooling for neuroprotection.
Area of Science:
- Neurology
- Medical Devices
- Therapeutic Hypothermia
Background:
- Acute brain lesions pose a significant public health risk.
- Neuroprotective therapies, like hypothermia, aim to improve outcomes.
- Whole-body cooling has limitations due to adverse events, prompting research into selective methods like nasopharyngeal cooling.
Purpose of the Study:
- To evaluate the efficacy of a novel nasopharyngeal catheter in reducing brain temperature.
- To assess the safety and effectiveness of selective brain cooling via a nasopharyngeal approach.
Main Methods:
- A prospective, non-randomized, interventional trial was conducted on 10 pigs.
- Nasopharyngeal cooling was administered for 60 minutes using a novel catheter inserted into the nasopharyngeal cavity.
- Rewarming was performed for 15 minutes post-cooling.
Main Results:
- Nasopharyngeal cooling significantly decreased brain temperature, particularly in the left cerebral hemisphere.
- Brain temperature dropped by up to 4.45°C within one hour, with a brain-core gradient of 4.57°C.
- Vital signs and hemodynamic parameters remained stable; no mucosal lesions were observed.
Conclusions:
- A novel nasopharyngeal cooling catheter effectively induced selective brain cooling in pigs.
- The method was safe, with no device-related local or systemic complications.
- Exclusive brain cooling may be beneficial for specific patient populations requiring neuroprotection.
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