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A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Estimation of Probability Distribution and Its Application in Bayesian Classification and Maximum Likelihood
Hao Dai1,2, Wei Wang3, Qin Xu1
1State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
Nonparametric estimation of cumulative distribution function and probability density function of continuous random variables is a basic and central problem in probability theory and statistics. Although many methods such as kernel density estimation have been presented, it is still quite a challenging problem to be addressed to researchers. In this paper, we proposed a new method of spline regression, in which the spline function could consist of totally different types of functions for each segment with the result of Monte Carlo simulation. Based on the new spline regression, a new method to estimate the distribution and density function was provided, which showed significant advantages over the existing methods in the numerical experiments. Finally, the density function estimation of high dimensional random variables was discussed. It has shown the potential to apply the method in classification and regression models.
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