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Related Concept Videos

Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Structural Isomerism02:34

Structural Isomerism

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Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
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Structure of Lipids03:38

Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Viral Structure00:56

Viral Structure

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Related Experiment Video

Updated: Jan 22, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

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Structural Insights into Rotavirus Entry.

Javier M Rodríguez1, Daniel Luque2

  • 1Centro Nacional de Microbiología/ISCIII, Madrid, Spain. j.rodriguez@isciii.es.

Advances in Experimental Medicine and Biology
|July 19, 2019
PubMed
Summary
This summary is machine-generated.

Rotaviruses, a cause of diarrheal disease, infect cells through a complex entry process. This review details the structure and dynamics of rotavirus

Keywords:
EntryMulti-layered particleNon-enveloped virusRotavirus entryStructural changesStructural virologyViral receptor

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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

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Area of Science:

  • Virology
  • Structural Biology
  • Cellular Biology

Background:

  • Rotaviruses are non-enveloped dsRNA viruses responsible for significant diarrheal disease in infants and animals.
  • Viral infection requires cell recognition and membrane penetration, often via pore formation or lysis.

Purpose of the Study:

  • To review the structure and dynamics of the rotavirus entry machinery.
  • To survey current models of rotavirus cell entry.

Main Methods:

  • Analysis of structural information on rotavirus over the past 30 years.
  • Focus on the viral proteins involved in cell entry.

Main Results:

  • Rotavirus entry is initiated by viral spike interaction with cell surface glycan ligands.
  • Conformational changes in outer capsid proteins drive the entry process.

Conclusions:

  • Understanding rotavirus entry machinery is crucial for combating viral infections.
  • Structural dynamics play a key role in the complex multistep entry process.