Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Recombination00:57

Viral Recombination

25.0K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.0K
Viral Structure00:56

Viral Structure

74.0K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.0K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

260
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
260
Hepatic Portal System01:21

Hepatic Portal System

5.5K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
5.5K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

219
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
219
Viral Mutations00:36

Viral Mutations

39.8K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the GALA Study Group.

Liver international : official journal of the International Association for the Study of the Liver·2025
Same author

Arterial structure and function in children with inflammatory bowel disease.

JGH open : an open access journal of gastroenterology and hepatology·2024
Same author

Impact of ulcerative colitis on liver-related outcomes of children with primary sclerosing cholangitis.

Journal of paediatrics and child health·2022
Same author

Paediatric liver transplantation in Australia and New Zealand: 1985-2018.

Journal of paediatrics and child health·2020

Related Experiment Video

Updated: Jan 22, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.8K

Viral hepatitis.

Winita Hardikar1

  • 1Department of Gastroenterology, Royal Children's Hospital, Melbourne, Victoria, Australia.

Journal of Paediatrics and Child Health
|July 19, 2019
PubMed
Summary

Hepatitis viruses A-E can cause abnormal liver function in children. This review updates the diagnosis and treatment of viral hepatitis in Australian children, reflecting recent advancements.

Area of Science:

  • Pediatric Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis viruses A through E are known causes of abnormal liver function tests in pediatric populations.
  • While uncommon in Australian children, the epidemiology, diagnosis, and treatment of viral hepatitis have seen significant evolution.
  • Understanding these changes is crucial for effective pediatric care.

Purpose of the Study:

  • To provide an updated review on the diagnosis and treatment of viral hepatitis in children.
  • To consolidate current knowledge on hepatitis A-E in the pediatric demographic.
  • To inform healthcare professionals on recent advancements in managing pediatric viral hepatitis.

Main Methods:

  • Literature review of recent studies and guidelines.
Keywords:
childrenhepatitis Bhepatitis Cviral hepatitis

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.8K
A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K
  • Synthesis of epidemiological data.
  • Analysis of diagnostic and therapeutic advancements.

    • Main Results:

    • Hepatitis viruses A-E can manifest with abnormal liver function tests in children.
    • Epidemiological patterns, diagnostic approaches, and treatment strategies have evolved.
    • Current management reflects a decade of progress in the field.

    Conclusions:

    • Viral hepatitis remains a relevant concern in pediatric medicine, despite its relative rarity.
    • Updated diagnostic and treatment protocols are essential for optimal outcomes in children.
    • This review highlights key developments for clinicians managing pediatric viral hepatitis.