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Efficacy of uric acid-lowering therapy on hypercholesterolemia and hypertriglyceridemia in gouty patients

Jing Wu1, Yu-Ping Zhang1, Yuan Qu1

  • 1Department of Rheumatology and Clinical Immunology, ZhuJiang Hospital, Southern Medical University, Guangzhou, China.

International Journal of Rheumatic Diseases
|July 19, 2019
PubMed

Insights

Uric acid-lowering therapy can improve hyperlipidemia in gout patients. Febuxostat demonstrated superior efficacy in reducing cholesterol and triglyceride levels compared to allopurinol and benzbromarone.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pharmacology

Background:

  • Gout patients often present with hyperlipidemia, a condition requiring management.
  • Uric acid-lowering therapy (UALT) is standard for gout, but its impact on lipid profiles is of interest.

Purpose of the Study:

  • To evaluate the effects of Uric Acid-Lowering Therapy (UALT) on hypercholesterolemia and hypertriglyceridemia in patients with gout.
  • To compare the efficacy of febuxostat, allopurinol, and benzbromarone in managing dyslipidemia in this population.

Main Methods:

  • Retrospective study of 124 gout patients with hyperlipidemia from January 2015 to December 2017.
  • Patients received either febuxostat (52), allopurinol (29), or benzbromarone (43).
  • Serum cholesterol and triglyceride levels were analyzed after 8-10 weeks of UALT.

Main Results:

  • All UALT agents showed mild effects on serum cholesterol and triglyceride levels.
  • Febuxostat significantly reduced both cholesterol and triglyceride levels in patients not on lipid-lowering medication.
  • Allopurinol and benzbromarone showed modest reductions in triglycerides, with no significant impact on cholesterol.

Conclusions:

  • UALT offers benefits for hyperlipidemia management in gout patients.
  • Febuxostat is more effective than allopurinol and benzbromarone in improving lipid profiles in gout patients with hyperlipidemia.
Abstract

Keywords:
febuxostatgouthypercholesterolemiahypertriglyceridemia

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