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Updated: Jan 22, 2026

Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration
Published on: March 7, 2019
Process optimisation, biocompatibility and anti-cancer efficacy of curcumin loaded gelatine microparticles
Zeynep Kocer1,2, Basak Aru3, Umran Aydemir Sezer4,5
1Department of Chemical Engineering, Yildiz Technical University , Istanbul , Turkey.
Abstract:
In this study, we produced curcumin loaded gelatine microparticles, through spray-drying method, with dialdehyde carboxymethyl cellulose (DCMC) which is introduced as a new cross-linking agent for drug delivery systems and examined toxicities by comparison of traditional cross-linking agents. We employed various parameters in the production and tried to develop the most efficient drug delivery system through Taguchi method by examining efficiencies on gastric cancer under in vitro conditions. The results indicated gelatine microparticles cross-linked with DCMC offers more biocompatible drug delivery systems. The particle size of the microparticles produced via different parameters varies from 1.926 to 3.357 µm. Curcumin was substantially remained stable after 6 months. This study indicates potential use of DCMC cross-linked gelatine microparticles as drug delivery vehicle.
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