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Novel topical and systemic therapies in atopic dermatitis

Hiraku Suga1, Shinichi Sato1

  • 1Department of Dermatology, Faculty of Medicine, The University of Tokyo , Tokyo , Japan.

Immunological Medicine
|July 19, 2019
PubMed

Insights

New topical and systemic therapies show promise for atopic dermatitis (AD) treatment. Emerging agents like phosphodiesterase 4 inhibitors and Janus kinase (JAK) inhibitors offer effective options for managing this common inflammatory skin disease.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Atopic dermatitis (AD) is a prevalent inflammatory skin condition with significant psychological and social impact.
  • Conventional systemic immunotherapies for severe AD have limitations due to adverse effects like nephrotoxicity and malignancy risks.
  • Dupilumab, targeting IL-4 and IL-13, is an established effective treatment for AD.

Purpose of the Study:

  • To review the efficacy and safety of current topical and systemic therapies for atopic dermatitis.
  • To summarize findings from recently published phase II/III clinical trials on novel AD treatments.

Main Methods:

  • Systematic review of published phase II/III clinical trials on atopic dermatitis therapies.
  • Analysis of efficacy and safety data for emerging topical and systemic agents.

Main Results:

  • Topical phosphodiesterase 4 inhibitors and Janus kinase (JAK) inhibitors demonstrate potential as effective AD treatments.
  • Systemic therapies, including biologics targeting IL-13 and oral JAK inhibitors, exhibit strong efficacy in managing AD.
  • Novel agents are emerging, heralding a new era in AD therapeutic options.

Conclusions:

  • Emerging topical and systemic therapies offer promising advancements in atopic dermatitis management.
  • Further research and clinical trials are essential to fully establish the role of these novel agents in AD treatment protocols.
Keywords:
Atopic dermatitisJAK inhibitordupilumabeczema

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