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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Sliding mode controller-observer pair for p53 pathway.

Muhammad Rizwan Azam1, Vadim I Utkin2, Ali Arshad Uppal3

  • 1CASPR, Department of Electronics Engineering, Capital University of Science & Technology, Islamabad, Pakistan.

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|July 19, 2019
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Summary
This summary is machine-generated.

This study introduces a dynamic sliding mode control (DSMC) method to manage drug delivery for restoring anti-tumor p53 protein levels in early cancer. DSMC offers a smoother control signal and reduced energy consumption compared to conventional methods.

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Area of Science:

  • Biomedical Engineering
  • Control Theory
  • Cancer Research

Background:

  • Wild-type p53 protein, a crucial anti-tumor agent, is often lost in early cancerous cells.
  • Restoring p53 levels using small molecule drugs is a key therapeutic strategy.
  • Conventional sliding mode control (SMC) generates discontinuous control signals unsuitable for continuous drug infusion.

Purpose of the Study:

  • To design a robust, non-linear control strategy for p53 drug design.
  • To develop a smooth control signal for continuous drug administration using dynamic SMC (DSMC).
  • To estimate unknown system states using a reduced-order sliding mode observer.

Main Methods:

  • A control-oriented p53 model was developed.
  • Dynamic Sliding Mode Control (DSMC) was designed for smooth control input.
  • A reduced-order sliding mode observer was employed for state estimation.
  • Robustness was tested against input disturbance and parametric uncertainty.

Main Results:

  • The proposed DSMC technique effectively achieves sustained p53 levels through controlled drug administration.
  • The boundedness of the zero-dynamics was mathematically proven.
  • In-silico trials confirmed the effectiveness of the control scheme.
  • DSMC demonstrated comparable performance to conventional SMC but with lower energy consumption.

Conclusions:

  • DSMC provides a robust and efficient method for controlling drug delivery to maintain therapeutic p53 levels.
  • The developed observer accurately estimates system states for model-based control.
  • This approach offers a promising strategy for cancer therapy through precise drug administration.