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Published on: June 13, 2025
Endoscopic closure of large colonic perforations with a novel endoscopic clip device: An animal study (with videos)
Zhi-Jie Wang1,2, Shi-Yu Li2, Yan-Hui Zhang2
1Department of Gastroenterology, Gongli Hospital, Second Military Medical University, Shanghai, China.
Background And Aim:
An endoscopic clip device was newly designed to accomplish the closure of large gastrointestinal defects. The aim of this study was to determine the feasibility and efficacy of this device in an ex vivo experimental setting.
Methods:
This prospective study was conducted in porcine colons (n = 5). A large (3-4 cm) linear full-thickness incision was created using a scalpel externally. The device was used for endoscopic closure. The procedure time, number of clips, and success rate of closure were determined.
Results:
Ten defects were created in five porcine colons (two incisions in each specimen). Successful closure was achieved in all defects. The mean procedure time was 24.30 ± 4.42 min, the mean leak pressure is 28.30 ± 9.49 mmHg, and the mean number of additional conventional hemostatic clips used was 5.10 ± 0.99.
Conclusions:
The results indicated that this clip achieved the convenient and reliable closure of large defects in the colon wall in an ex vivo porcine model and seems to be a promising option for closing large gastrointestinal perforations.
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