Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

807
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
807
Correlations02:20

Correlations

35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Correlation and Causation01:27

Correlation and Causation

42.1K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.1K
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

14.9K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
14.9K
Constant Pressure Calorimetry03:02

Constant Pressure Calorimetry

97.4K
Calorimetry is a technique used to measure the amount of heat involved in a chemical or physical process or to measure the heat transferred to or from a substance. The heat is exchanged with a calibrated and insulated device called the calorimeter. Calorimetry experiments are based on the assumption that there is no heat exchange between the insulated calorimeter and the external environment. The well-insulated calorimeters prevent the transfer of heat between the calorimeter and its external...
97.4K
Constant Volume Calorimetry02:41

Constant Volume Calorimetry

30.6K
Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
30.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing experimental parameters for biphasic transfer in vitro lipolysis model.

International journal of pharmaceutics·2026
Same author

Preformulation studies of levonorgestrel: A supplier variation analysis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Development of high-concentration long-acting injectable formulations of TBAJ-587 and TBAJ-876 as an extended treatment strategy against tuberculosis.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Impact of solvent choice during microfluidic manufacture on the in vivo performance of liposomal doxorubicin.

Drug delivery and translational research·2026
Same author

In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs.

Pharmaceutics·2026
Same author

Accelerating Generic Long-Acting Antiretrovirals for Global HIV Treatment: Workshop Findings and a Roadmap to Access.

Clinical pharmacology and therapeutics·2026

Related Experiment Video

Updated: Jan 22, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K

Correlation between the stability constant and pH for β-cyclodextrin complexes.

Lisa Samuelsen1, René Holm2, Audrey Lathuile3

  • 1Department of Science and Environment, Roskilde University, Universitetsvej 1, DK-4000 Roskilde, Denmark.

International Journal of Pharmaceutics
|July 19, 2019
PubMed
Summary
This summary is machine-generated.

Formulation scientists can now predict cyclodextrin drug complex stability across pH using a new theoretical model. This aids in optimizing drug solubility and stability for better formulations.

Keywords:
Drug formulationEquilibrium constantGuest moleculeHydrophobic interactionsIonizationpH-dependency

More Related Videos

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K

Related Experiment Videos

Last Updated: Jan 22, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K
Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.7K

Area of Science:

  • Pharmaceutical Science
  • Physical Chemistry

Background:

  • Cyclodextrins enhance drug solubility and stability by forming inclusion complexes.
  • Drug complexation strength with cyclodextrins is pH-dependent, requiring a balance between solubility and stability.

Purpose of the Study:

  • To develop a theoretical expression predicting cyclodextrin-drug complex stability constants as a function of pH.
  • To validate the theoretical model with experimental data and literature findings.

Main Methods:

  • Determined stability constants for beta-cyclodextrin and ibuprofen complexes using isothermal titration calorimetry across various pH and temperatures.
  • Collected and analyzed ten additional datasets from literature involving different drugs and cyclodextrins.

Main Results:

  • A theoretical expression accurately predicted pH-dependent stability constants for cyclodextrin-drug complexes.
  • Experimental data and literature data confirmed the model's ability to account for observed pH dependencies.

Conclusions:

  • The presented theoretical expression enables accurate prediction of cyclodextrin complex stability constants at any given pH.
  • This model aids formulation scientists in optimizing drug solubility and cyclodextrin complex stability.