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Updated: Jan 22, 2026
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
Published on: July 3, 2018
Noncovalent interactions between isoflurane and dimethyl ether. Spectroscopic evidence of trimer formation
S M Melikova1, K S Rutkowski1, M Rospenk2
1Department of Physics, Saint Petersburg State University, 7/9 Universitetskaya Nab., 199034 Saint Petersburg, Russian Federation.
Abstract:
The IR spectra of isoflurane + dimethyl ether mixtures dissolved in liquid Kr are registered at T ~118-160 K. The results obtained at a wide range of relative concentrations suggest the formation of complexes stabilized by non-covalent interactions of H-bond type. Large excess of DME and low temperature favor trimer formation stabilized by interactions between two DME moieties and both CH groups of isoflurane predominantly. Estimations based on ab initio calculation of spectroscopic and thermodynamic parameters confirm the experimental findings.
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