Related Experiment Video
Updated: Jan 22, 2026
10:10
Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
Published on: November 13, 2021
9.5K
Towards Lateral Flow Quantitative Assays: Detection Approaches.
Alexandr E Urusov1, Anatoly V Zherdev1, Boris B Dzantiev2
1A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia.
Biosensors
|July 20, 2019
Summary
Point-of-care (POC) testing using lateral flow assays is advancing. This review explores new detection methods for objective, quantitative results beyond visual assessment in diagnostics and monitoring.
Area of Science:
- Biomedical Diagnostics
- Analytical Chemistry
- Biosensor Technology
Background:
- Point-of-care (POC) or bedside analysis is a significant trend in modern diagnostics.
- Lateral flow (immunochromatographic) test strips are widely used for rapid biomarker detection.
- Traditional lateral flow tests often rely on subjective visual assessment, limiting objectivity and quantitative output.
Purpose of the Study:
- To review current and emerging methods for detecting, processing, and interpreting immunochromatographic assay results.
- To highlight advancements that enable quantitative analysis from lateral flow assays.
- To discuss the potential of modern portable detectors for improved diagnostic information.
Main Methods:
- Review of literature on lateral flow assay detection technologies.
- Discussion of portable detector capabilities for various label types (colored, fluorescent, magnetic, conductive).
- Analysis of data processing and interpretation strategies for immunochromatographic tests.
Main Results:
- Traditional visual assessment of lateral flow tests is a limitation.
- Modern portable detectors offer quantitative analysis using diverse labels.
- Advanced methods improve objectivity and information output from lateral flow assays.
Conclusions:
- There is a need for quantitative lateral flow assays to overcome limitations of visual assessment.
- Portable detectors registering various labels show promise for enhanced POC diagnostics.
- Further development in detection and interpretation is crucial for advancing lateral flow technology.
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