Related Experiment Video

Updated: Jan 22, 2026

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
09:02

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate

Published on: June 18, 2020

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Yeast as a Tool for Deeper Understanding of Human Manganese-Related Diseases

Louise Thines1, Antoine Deschamps1, Jiri Stribny1

  • 1Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.

Genes
|July 20, 2019
PubMed

Insights

Manganese is vital for enzymes and antioxidant defense. Disruptions in manganese homeostasis can lead to human diseases, with yeast models offering insights into cellular regulation and pathology.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Human Pathology

Background:

  • Manganese is essential for human health, acting as a cofactor for enzymes and an antioxidant.
  • Imbalances in manganese levels (homeostasis) are linked to various human diseases.
  • Yeast cells serve as valuable models for studying cellular manganese regulation.

Purpose of the Study:

  • To review manganese homeostasis in yeast and its relevance to human cells.
  • To explore manganese-related human pathologies using yeast models.
  • To connect manganese's roles in enzymatic function and antioxidant defense to disease mechanisms.

Main Methods:

  • Literature review of yeast and human cellular manganese regulation.
  • Analysis of yeast models for studying manganese homeostasis.
  • Examination of specific human pathologies linked to manganese dysregulation.

Main Results:

  • Yeast models effectively elucidate cellular mechanisms for controlling manganese concentration.
  • Knowledge from yeast studies is transferable to understanding human manganese metabolism.
  • Specific diseases like TMEM165-CDG, Friedreich ataxia, Kufor-Rakeb syndrome, and prion diseases are discussed in relation to manganese.

Conclusions:

  • Yeast provides a powerful system for investigating manganese biology and its role in human health.
  • Understanding manganese homeostasis is crucial for deciphering the molecular basis of associated pathologies.
  • Further research in yeast can illuminate therapeutic strategies for manganese-related disorders.
Keywords:
Friedreich ataxiaKufor-RakebTMEM165-CDGantioxidantcofactordiseasemanganeseneurodegenerationprion diseasesyeast

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