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Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures

Yasser K Rashed1, Mohamed El-Guindi2

  • 1Department of Pediatric Hepatology, National Liver Institute, Menoufiya University, Menoufia, Egypt.

Korean Journal of Pediatrics
|July 20, 2019
PubMed

Insights

Topical Mitomycin C combined with esophageal dilatation effectively treats resistant esophageal strictures in children. This approach showed excellent results with no reported side effects in a 3-5 year follow-up.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Surgery

Background:

  • Esophageal strictures, often benign, are common GI tract issues, particularly in children due to caustic ingestion in developing nations.
  • Topical Mitomycin C has shown promise in various medical applications.

Purpose of the Study:

  • To assess the effectiveness and safety of Mitomycin C for treating pediatric esophageal strictures.
  • To evaluate the methodology and clinical outcomes of Mitomycin C treatment.

Main Methods:

  • The study involved 30 children with resistant esophageal strictures.
  • Procedures included upper GI endoscopy, esophageal dilatation, and topical Mitomycin C application under direct endoscopic vision.
  • Patients were monitored for 3-5 years post-treatment.

Main Results:

  • Excellent clinical and endoscopic response was observed in 93.3% of patients (28/30).
  • A good endoscopic response was noted in 6.7% of patients (2/30).
  • No adverse side effects were reported with topical Mitomycin C use.

Conclusions:

  • Esophageal dilatation with topical Mitomycin C application is a potentially effective strategy for resistant esophageal strictures.
  • This combined approach offers a promising treatment option for pediatric patients.
Abstract

Keywords:
Corrosive esophagitisEsophageal strictureMitomycin C

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