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A polycentric, randomized, parallel-group, study on Lertal®, a multicomponent nutraceutical, as preventive treatment

Gianluigi Marseglia1, Amelia Licari1, Salvatore Leonardi2

  • 1Pediatrics Clinic, Pediatrics Department, Policlinico San Matteo, University of Pavia, Pavia, Italy.

Italian Journal of Pediatrics
|July 20, 2019
PubMed

Insights

This study found that Lertal®, a nutraceutical, significantly reduced allergic rhinitis (AR) exacerbations in children. Continued Lertal® use halved the risk and duration of AR symptoms, ensuring longer symptom-free periods.

Area of Science:

  • Allergy and Immunology
  • Pediatrics
  • Nutraceutical Research

Background:

  • Allergic rhinitis (AR) poses a significant health challenge in children.
  • Nutraceuticals offer a potential avenue for managing chronic conditions like AR.
  • Lertal®, containing Perilla extract, quercetin, and Vitamin D3, was investigated for its efficacy in AR management.

Purpose of the Study:

  • To evaluate the efficacy and safety of Lertal® in preventing allergic rhinitis exacerbations in children.
  • To assess the impact of Lertal® on the frequency, intensity, and duration of AR exacerbations.
  • To determine the effect of Lertal® on symptom-free time in pediatric AR patients post-pharmacological treatment.

Main Methods:

  • A polycentric, randomized, parallel-group, controlled Phase II study was conducted.
  • 128 children with AR were divided into two groups: continued Lertal® (LG) or no medication (OG) for 4-12 weeks.
  • Study endpoints included AR exacerbation rates, intensity, duration, and symptom-free intervals.

Main Results:

  • Lertal® group (LG) showed a 54% reduced risk of AR exacerbations compared to the observation group (OG).
  • LG patients experienced significantly fewer AR exacerbations and required less rescue medication.
  • Prolonged Lertal® use was associated with significantly longer symptom-free periods and no adverse events.

Conclusions:

  • Lertal® is a safe and effective nutraceutical for preventing allergic rhinitis exacerbations in children.
  • Sustained Lertal® intake significantly reduces AR symptom severity, duration, and the need for rescue medications.
  • Lertal® demonstrates potential as a long-term preventive strategy for pediatric allergic rhinitis, promoting extended symptom relief.
Abstract

Keywords:
Allergic rhinoconjunctivitisExacerbationNutraceuticalPerilla frutescensPreventive treatmentQuercetinVitamin D3

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