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Updated: Jan 22, 2026
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Evaluation of maximum standardized uptake value at fluorine-18 fluorodeoxyglucose positron emission tomography as a
Hyungjin Kim1, Jin Mo Goo2, Jin Chul Paeng3
1Department of Radiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Objectives:
This retrospective cohort study aimed to analyze the prognostic effect of maximum standardized uptake value (SUVmax) as a complementary T factor in addition to the clinical T category of the eighth-edition staging system for the prediction of disease-free survival (DFS) in patients with resected lung adenocarcinomas.
Materials And Methods:
A total of 572 patients (male:female = 235:337; median age, 64 years) with clinical stage I (T1-T2aN0M0) adenocarcinomas underwent preoperative fluorine-18 fluorodeoxyglucose positron emission tomography and subsequent lobectomy between 2009 and 2015. The prognostic values of SUVmax and PETT category [categorized SUVmax; PETT1 (SUVmax ≤2), PETT2 (2< SUVmax ≤7), and PETT3 (SUVmax >7)] in conjunction with the clinical T category were analyzed using a multivariable Cox regression and a likelihood-ratio test, respectively. The clinical T category was then upstaged or downstaged (cTModified) based on PETT. This new categorization system was evaluated using a Cox regression and then compared with the clinical T category.
Results:
Multivariable-adjusted Cox regression revealed that SUVmax and PETT were independent and significant predictors with the current clinical T category for DFS. Regarding SUVmax, the adjusted hazard ratio (HR) was 1.048 (95% CI: 1.009, 1.089; P = 0.017). Regarding PETT, the adjusted HRs were 2.365 (95% CI: 1.034, 5.406; P = 0.041) in PETT2 and 3.005 (95% CI: 1.258, 7.179; P = 0.013) in PETT3. The inclusion of the PET-derived factors substantially improved the model fit (P < 0.05). cTModified was a significant predictor of DFS, which improved the prognostic discrimination of lung adenocarcinomas.
Conclusion:
SUVmax and PETT are independent prognostic factors after adjustment for the clinical T category. The PETT category could be used to adjust the clinical T category preoperatively.
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