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Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
Carboxymethylated starch and cellulose derivatives-based film as human skin equivalent for adhesive properties
Adrian Krzysztof Antosik1, Agnieszka Piątek2, Katarzyna Wilpiszewska3
1West Pomeranian University of Technology, Faculty of Chemical Technology and Engineering, Institute of Organic Chemical Technology, ul. Pulaskiego 10, 70-322 Szczecin, Poland.
Abstract:
The films based on carboxymethyl derivatives of starch (CMS) and cellulose (CMC) were proposed as a novel human skin equivalent. The physicochemical properties (moisture absorption, solubility in water, mechanical properties) of CMS/CMC films were evaluated. Additionally, some properties were compared to the human skin ones (surface roughness, tribology). The system based on CMS/CMC 25/75 wt. % was selected for testing the adhesive properties of pressure-sensitive adhesives commonly used for medical purposes (acrylic, silicone and polyisobutylene). Similar tests were performed for human skin. The peel adhesion values for CMS/CMC film and human skin were similar for all adhesives types tested. Applying such a skin equivalent allows to evaluate the functional properties of medical pressure-sensitive adhesives without the ethical and economic issues.
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