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Elimination of UV-resistance inducing effect of R46 R factor by 5-fluorouracil
I Francia1, Z Hernádi, M Szabolcs
1Central Research Laboratory, University Medical School, Debrecen, Hungary.
Acta Biochimica Et Biophysica Hungarica
|January 1, 1987
Abstract:
R-factor curing capacity of 5-fluorouracil (5-FU) was studied. Well detectable increase in UV-resistance was found in E. coli K12 AB1157 strain and its recB-, recC-, recF- mutants harbouring R46 R-factor. After treatment with 5-FU, these strains lost not only the antibiotic resistance coded for R46 R-factor but their UV-radioresistance, as well.