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Lyon-IARC Polyomavirus DNA in Feces of Diarrheic Cats

Elizabeth Fahsbender1,2, Eda Altan1,2, Marko Estrada3

  • 1Vitalant Research Institute, San Francisco, California, USA.

Microbiology Resource Announcements
|July 20, 2019
PubMed

Insights

A novel virus, Lyon-IARC polyomavirus (LIPyV), was detected in cats experiencing diarrhea. This finding suggests LIPyV may be a cause of feline gastrointestinal illness.

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases
  • Viral Metagenomics

Background:

  • An unexplained outbreak of feline diarrhea prompted an investigation into potential viral etiologies.
  • Lyon-IARC polyomavirus (LIPyV) is a virus with a genome previously sequenced from human skin swabs.

Purpose of the Study:

  • To identify the causative agent of an unexplained feline diarrhea outbreak.
  • To investigate the presence and shedding of Lyon-IARC polyomavirus in diarrheic domestic cats.

Main Methods:

  • Fecal samples from diarrheic cats were analyzed using viral metagenomic techniques.
  • Polyomavirus DNA presence was detected in the samples.

Main Results:

  • Viral metagenomic analysis revealed the presence of Lyon-IARC polyomavirus (LIPyV) DNA in the feces of affected cats.
  • Three out of five diarrheic cats shed LIPyV DNA in their feces.
  • The genome of LIPyV was originally sequenced from human skin swabs.

Conclusions:

  • Lyon-IARC polyomavirus is detected in cats with diarrhea, suggesting a potential role in feline gastrointestinal disease.
  • Fecal shedding of LIPyV occurs in domestic cats, expanding the known host range and transmission routes for this virus.

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