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The microRNA in ventricular remodeling: the miR-30 family

Xiaonan Zhang1, Shaoyang Dong2, Qiujin Jia1

  • 1Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Bioscience Reports
|July 20, 2019
PubMed

Insights

MicroRNA-30 (miR-30) plays a key role in ventricular remodeling (VR) by influencing processes like apoptosis and fibrosis. Understanding miR-30 mechanisms is crucial for treating cardiovascular diseases (CVDs).

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Biomedical Research

Background:

  • Ventricular remodeling (VR) involves cardiomyocyte apoptosis, hypertrophy, and fibrosis, driven by cardiovascular diseases (CVDs) like hypertension and heart failure (HF).
  • VR is an independent risk factor for CVDs, leading to impaired heart function, increased cardiovascular events, and mortality.
  • MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and are implicated in various CVDs.

Purpose of the Study:

  • To review the mechanisms by which the microRNA-30 (miR-30) family influences ventricular remodeling (VR).
  • To explore the role of miR-30 in VR across diverse conditions including ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), and cardiotoxicity (CTX).

Main Methods:

  • Literature review of studies investigating miR-30 and VR.
  • Analysis of molecular mechanisms including autophagy, apoptosis, oxidative stress, and inflammation.
  • Synthesis of findings related to miR-30's involvement in various disease-induced VR models.

Main Results:

  • The miR-30 family is abundant in the heart and significantly impacts VR.
  • miR-30 regulates key pathological processes in VR, such as autophagy, apoptosis, oxidative stress, and inflammation.
  • Dysregulation of miR-30 is associated with VR in multiple CVD contexts.

Conclusions:

  • The miR-30 family is a critical regulator of ventricular remodeling.
  • Targeting miR-30 pathways offers potential therapeutic strategies for managing VR in various cardiovascular diseases.
  • Further research into miR-30's specific roles can advance treatments for heart conditions.

Keywords:
apoptosisautophagyinflammationmiR-30 familyoxidative stressventricular remodeling

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