Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

4.8K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
4.8K
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

381
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
381
Abdominal Aorta01:25

Abdominal Aorta

2.1K
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
2.1K
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

264
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
264
Ultrasound I: Abdominal Ultrasonography01:20

Ultrasound I: Abdominal Ultrasonography

1.4K
Introduction:
Abdominal ultrasonography, commonly known as abdominal ultrasound, is a vital, non-invasive medical imaging technique widely used in healthcare.
Procedure:
This diagnostic tool allows the clinician to visually inspect internal structures within the abdomen, including vital organs such as the liver, gallbladder, pancreas, kidneys, and spleen.
The abdominal ultrasound process begins with applying a special gel to the patient's skin over the abdomen. This gel enhances the...
1.4K
Abdominal Regions and Quadrants01:19

Abdominal Regions and Quadrants

16.7K
To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical efficacy and predictive model development for levetiracetam in children with newly diagnosed epilepsy of unknown etiology.

Translational pediatrics·2026
Same author

Associations of complement proteins and immunoglobulins with cognitive impairment in type 2 diabetes mellitus: a cross-sectional study.

BMC endocrine disorders·2026
Same author

Research on the generalization of a blood donor recruitment framework based on machine learning.

BMC medical informatics and decision making·2026
Same author

Air restriction enhances <i>Streptococcus mutans</i> cariogenicity via preferential lactose metabolism.

Microbiology spectrum·2026
Same author

Humoral immunity and infection status of PLWH following vaccination after the BA.5/BF.7 wave.

Frontiers in microbiology·2026
Same author

PAK5 drives vascular remodeling in hypoxic pulmonary hypertension via Drp1-dependent mitochondrial midzone division.

Scientific reports·2026

Related Experiment Video

Updated: Jan 22, 2026

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
04:49

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase

Published on: February 11, 2022

6.1K

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.

Huimin Yan1,2, Ying Hu1,2, Antonina Akk1,2

  • 1John Cochran VA Medical Center, Saint Louis, Missouri, USA.

Scientific Reports
|July 20, 2019
PubMed
Summary

Blocking interleukin-12p40 (IL-12p40) early in abdominal aortic aneurysm (AAA) development reduces inflammation and disease progression. This suggests IL-12p40 and IL-23 blockade are promising therapeutic strategies for AAA.

More Related Videos

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

Published on: July 23, 2009

25.2K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

4.4K

Related Experiment Videos

Last Updated: Jan 22, 2026

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
04:49

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase

Published on: February 11, 2022

6.1K
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

Published on: July 23, 2009

25.2K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

4.4K

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Inflammation Research

Background:

  • Macrophages are key players in abdominal aortic aneurysm (AAA) pathogenesis.
  • Pro-inflammatory cytokines like IL-12p40 and MMP-9 are elevated in AAA, particularly in later disease stages.

Purpose of the Study:

  • To investigate the role of IL-12p40 in early AAA development.
  • To evaluate the therapeutic potential of blocking IL-12p40 and IL-23 in AAA.

Main Methods:

  • Utilized mouse models of AAA.
  • Administered IL-12p40 and IL-23p19 blockade during early aneurysm development.
  • Assessed macrophage populations, cytokine levels, and MMP-9 activity.

Main Results:

  • Early blockade of IL-12p40 significantly suppressed macrophage expansion, inflammatory cytokine production, and MMP-9 levels.
  • IL-12p40 blockade mitigated AAA development.
  • Specific IL-23p19 blockade demonstrated comparable efficacy to IL-12p40 antagonism, indicating a potential role for IL-23 in AAA.

Conclusions:

  • IL-12p40 blockade is effective in suppressing early AAA progression.
  • The efficacy of IL-12p40 antagonism may be partly mediated by IL-23 blockade.
  • Targeting IL-12p40 or IL-23 presents a potential therapeutic strategy for AAA, leveraging existing FDA-approved drugs.