Related Experiment Video
Updated: Jan 22, 2026
04:49
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
Published on: February 11, 2022
6.1K
Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm
Huimin Yan1,2, Ying Hu1,2, Antonina Akk1,2
1John Cochran VA Medical Center, Saint Louis, Missouri, USA.
Scientific Reports
|July 20, 2019
Summary
Blocking interleukin-12p40 (IL-12p40) early in abdominal aortic aneurysm (AAA) development reduces inflammation and disease progression. This suggests IL-12p40 and IL-23 blockade are promising therapeutic strategies for AAA.
Area of Science:
- Cardiovascular Biology
- Immunology
- Inflammation Research
Background:
- Macrophages are key players in abdominal aortic aneurysm (AAA) pathogenesis.
- Pro-inflammatory cytokines like IL-12p40 and MMP-9 are elevated in AAA, particularly in later disease stages.
Purpose of the Study:
- To investigate the role of IL-12p40 in early AAA development.
- To evaluate the therapeutic potential of blocking IL-12p40 and IL-23 in AAA.
Main Methods:
- Utilized mouse models of AAA.
- Administered IL-12p40 and IL-23p19 blockade during early aneurysm development.
- Assessed macrophage populations, cytokine levels, and MMP-9 activity.
Main Results:
- Early blockade of IL-12p40 significantly suppressed macrophage expansion, inflammatory cytokine production, and MMP-9 levels.
- IL-12p40 blockade mitigated AAA development.
- Specific IL-23p19 blockade demonstrated comparable efficacy to IL-12p40 antagonism, indicating a potential role for IL-23 in AAA.
Conclusions:
- IL-12p40 blockade is effective in suppressing early AAA progression.
- The efficacy of IL-12p40 antagonism may be partly mediated by IL-23 blockade.
- Targeting IL-12p40 or IL-23 presents a potential therapeutic strategy for AAA, leveraging existing FDA-approved drugs.
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