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Cognitive impairment associated with increased mortality rate in patients with heart failure: A systematic review and

Jakrin Kewcharoen1,2, Narut Prasitlumkum1, Chanavuth Kanitsoraphan1

  • 1University of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.

Journal of the Saudi Heart Association
|July 20, 2019
PubMed

Insights

Cognitive impairment significantly increases mortality risk in heart failure patients. This meta-analysis confirms a strong association between cognitive decline and worse outcomes in individuals with heart failure, highlighting a critical area for further research.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Heart failure (HF) is associated with a higher prevalence of cognitive impairment compared to the general population.
  • The impact of cognitive impairment on cardiovascular outcomes in HF patients remains unclear.
  • This study addresses the need to understand the relationship between cognitive function and mortality in HF.

Purpose of the Study:

  • To systematically review and meta-analyze existing research.
  • To assess the association between cognitive impairment and mortality in heart failure patients.
  • To provide a pooled estimate of the risk of mortality in HF patients with cognitive impairment.

Main Methods:

  • Comprehensive literature search of MEDLINE and EMBASE databases up to October 2018.
  • Inclusion of cohort studies and randomized control trials evaluating cognitive impairment and mortality in HF.
  • Meta-analysis using a random-effects model to calculate pooled hazard ratios (HR) and 95% confidence intervals (CI).

Main Results:

  • Eight studies involving 3318 participants were analyzed.
  • 951 participants had diagnosed cognitive impairment.
  • Cognitive impairment was significantly associated with increased mortality risk in HF patients (pooled HR = 1.64, 95% CI = 1.42-1.88).

Conclusions:

  • Cognitive impairment is a significant predictor of increased mortality in the heart failure population.
  • A strong association exists between cognitive impairment and higher mortality risk in HF.
  • Further research is warranted to elucidate the underlying pathophysiology of this association.
Abstract

Keywords:
Cognitive dysfunctionHeart failureMortality

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