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ATAC-Seq Optimization for Cancer Epigenetics Research
Published on: June 30, 2022
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Key actors in cancer therapy: epigenetic modifiers
Remzi Okan Akar1, Selin Selvi1, Engin Ulukaya2
1Department of Cancer Biology and Pharmacology, Institute of Health Sciences, İstinye University, İstanbul, Turkey.
Turkish Journal of Biology = Turk Biyoloji Dergisi
|July 20, 2019
Summary
Epigenetic reprogramming influences cancer development and recurrence by altering gene expression. Targeting epigenetic modifiers offers new therapeutic strategies, including combinations, to combat cancer stem cells and metastasis.
Area of Science:
- Oncology
- Epigenetics
- Molecular Biology
Background:
- Epigenetic reprogramming, through DNA methylation and histone modifications, is fundamental to cancer biology.
- Aberrant epigenetic patterns are linked to cancer hallmarks like drug resistance, stemness, and metastasis.
- Epigenetic alterations critically regulate cancer stem cell properties, driving tumor recurrence and metastasis.
Purpose of the Study:
- To review epigenetic modifiers used in clinical and preclinical cancer therapy.
- To explore combination strategies targeting cancer stem cells and other cancer cells.
- To highlight the emerging role of epitranscriptomics in cancer treatment.
Main Methods:
- Literature review of epigenetic modifiers in cancer therapy.
- Analysis of clinical trials and preclinical studies.
- Discussion of combination strategies and epitranscriptomic targets.
Main Results:
- Epigenetic modifiers are established and emerging therapeutic targets in oncology.
- Combination therapies show promise for targeting diverse cancer cell populations.
- The epitranscriptome presents a novel frontier for cancer management.
Conclusions:
- Epigenetic dysregulation is a key driver of cancer, making epigenetic machinery a vital therapeutic target.
- Targeting cancer stem cells via epigenetic modifications is crucial for preventing recurrence and metastasis.
- The integration of epitranscriptomic insights may lead to more effective cancer therapies.
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