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Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
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Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?

Luciane Maria Oliveira Brito1, Haissa Oliveira Brito1, Rita da Graça Carvalhal Frazão Corrêa1

  • 1Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil.

Thescientificworldjournal
|July 20, 2019
PubMed

Insights

Human papillomavirus (HPV) infection is linked to coronary artery disease (CAD) in climacteric women. Women with HPV showed a significantly higher likelihood of developing CAD, especially with high-risk HPV types.

Area of Science:

  • Cardiology
  • Virology
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) are a major global health concern.
  • Emerging evidence suggests viral infections, including human papillomavirus (HPV), may contribute to atherosclerosis.
  • Data on the association between HPV infection and coronary artery disease (CAD) in women remains limited.

Purpose of the Study:

  • To explore the potential association between HPV infection and the presence of CAD in climacteric women.
  • To determine if HPV status is an independent risk factor for CAD in this demographic.

Main Methods:

  • A study involving 52 climacteric women investigated the presence of CAD and cervical HPV DNA.
  • Data on social, demographic, metabolic profiles, and cardiovascular risk factors were collected and analyzed.
  • Statistical analysis, including adjustment for confounding variables, was performed to assess the association.

Main Results:

  • A significant association was found between cervical HPV infection and CAD in climacteric women.
  • HPV-positive women demonstrated a 3.74 times higher odds of having CAD compared to HPV-negative women.
  • Infection with high-risk HPV types further increased the likelihood of CAD (OR = 4.90).

Conclusions:

  • The findings suggest a potential link between HPV infection and CAD in climacteric women.
  • HPV infection may represent an independent risk factor for CAD in this population.
  • Further research is warranted to elucidate the underlying biological mechanisms connecting HPV and cardiovascular health.
Abstract

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