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More from the Pipeline of Clinical Research on SELECTED SYSTEMIC THERAPIES FOR ATOPIC DERMATITIS

James Q Del Rosso1

  • 1Dr. Del Rosso is Research Director of JDR Dermatology Research in Las Vegas, Nevada; is with Thomas Dermatology in Las Vegas, Nevada; and is Adjunct Clinical Professor (Dermatology) with Touro University Nevada in Henderson, Nevada.

The Journal of Clinical and Aesthetic Dermatology
|July 20, 2019
PubMed

Many systemic therapies are under development for atopic dermatitis, many of which are injectable monoclonal antibodies that inhibit specific pathways involved in the pathogenesis of the disease. Most are currently under development, however, there are preliminary studies with subcutaneous omalizumab (IgE-directed therapy), and oral apremilast (phosphodiesterase-4 [PDE-4] inhibition. Further studies are needed with these agents. This article discusses various agents that address several potential therapeutic approaches, including IgE-directed therapy, anti-IL-31, anti-IL-5, anti-IL-22, PDE-4 inhibition, and thymic stromal lymphopoietin (TSLP)-directed therapy.

Keywords:
Atopic dermatitisImmunoglobulin E-directed therapyTSLPanti-IL-22anti-IL-31anti-IL-5phosphodiesterase-4targeted therapy

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