Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Attraction01:22

Local Attraction

364
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
364
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

1.2K
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.2K
Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

3.3K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
3.3K
Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

7.7K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
7.7K
Absolute and Local Extreme Values01:22

Absolute and Local Extreme Values

49
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
49
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

771
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
771

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Diagnosis of ATTR-CM Using Carpal Tunnel Biopsy Examination: EDUCATE: A United Kingdom Prospective Multicenter Study.

JACC. Heart failure·2026
Same author

Peripheral Neuropathy in p.Val142Ile (Val122Ile) Variant Hereditary Transthyretin-Mediated Amyloidosis: United Kingdom Experience.

Neurology. Genetics·2025
Same author

Redefining Cardiac Involvement and Targets of Treatment in Systemic Immunoglobulin AL Amyloidosis.

JAMA cardiology·2024
Same author

Should paediatric tonsillar asymmetry be an indication for tonsillectomy? A single centre experience.

The New Zealand medical journal·2024
Same author

Successful use of sclerotherapy in giant supraglottic vascular malformation.

BMJ case reports·2024
Same author

Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy.

Circulation·2024

Related Experiment Video

Updated: Jan 22, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K

Localized Sinonasal Amyloidosis.

Nur Wahidah Wahid1, Tarik Abed1, Sheneen Meghji1

  • 1ENT Department, Southend University Hospital, Westcliff-on-Sea, UK.

Allergy & Rhinology (Providence, R.I.)
|July 20, 2019
PubMed
Summary

Localized sinonasal amyloidosis is a rare condition. This case report details a non-amyloid A (AA) subtype, highlighting its rarity in the sinonasal tract.

Keywords:
amyloidosislocalizednasalnasopharyngealsinonasal

More Related Videos

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.3K
Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent
08:31

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Published on: November 30, 2017

12.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.3K
Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent
08:31

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Published on: November 30, 2017

12.9K

Area of Science:

  • Otorhinolaryngology
  • Pathology
  • Medical Research

Background:

  • Amyloidosis is a rare condition affecting the nasal mucosa, with limited documented cases.
  • Localized sinonasal amyloidosis presents unique diagnostic and management challenges.

Observation:

  • A 61-year-old male presented with a year-long history of left-sided nasal obstruction.
  • Endoscopic and CT imaging identified a nasal mass on the left inferior turbinate.
  • Biopsy confirmed amyloidosis, with systemic testing ruling out generalized disease.

Findings:

  • The diagnosis was localized sinonasal amyloidosis, specifically a non-amyloid A (AA) subtype.
  • This represents the second reported instance of a non-AA subtype within the sinonasal region.
  • Histopathology confirmed amyloid deposition without specific immunospecific staining.

Implications:

  • This case expands the understanding of rare sinonasal pathologies.
  • Highlights the importance of thorough investigation for localized amyloidosis.
  • Conservative management and close follow-up are crucial for localized sinonasal amyloidosis.