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Window of opportunity trials in head and neck cancer

Janice L Farlow1, Andrew C Birkeland2, Paul L Swiecicki3,4

  • 1Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Journal of Cancer Metastasis and Treatment
|July 20, 2019
PubMed

Insights

Window of opportunity trials in head and neck squamous cell carcinoma (HNSCC) offer insights into novel therapies. This review examines challenges and design considerations for future HNSCC early window studies.

Area of Science:

  • Oncology
  • Clinical Trials
  • Cancer Therapeutics

Background:

  • Head and neck squamous cell carcinoma (HNSCC) presents significant global health challenges with poor survival rates.
  • Current targeted and immunotherapies show limited clinical application beyond recurrent or metastatic HNSCC.
  • Early window studies are emerging as a strategy to evaluate novel agents in treatment-naïve HNSCC patients.

Purpose of the Study:

  • To review recent window of opportunity trials in HNSCC.
  • To discuss the challenges encountered in these early investigations.
  • To inform the design considerations for future HNSCC early window studies.

Main Methods:

  • Review of recent literature on window of opportunity trials in HNSCC.
  • Analysis of study designs, safety profiles, pharmacodynamics, and tumor responses.
  • Identification of potential biomarkers for treatment sensitivity or resistance.

Main Results:

  • Window of opportunity settings allow for safety, pharmacodynamic, and initial response assessments in treatment-naïve HNSCC.
  • These studies can identify biomarkers predictive of treatment outcomes.
  • Several challenges inherent to this trial design have been identified.

Conclusions:

  • Early window studies are valuable for evaluating novel therapies in HNSCC.
  • Addressing identified challenges is crucial for optimizing future trial designs.
  • Further research in this setting can improve therapeutic strategies for HNSCC.
Keywords:
Window of opportunity trialbiomarkerhead and neck canceroncologypreoperativetranslational researchtrials

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