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MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus
Thamiris Vaz Gago Prata1, Dayane de Souza Rodrigues da Silva1, Caroline Manchiero1
1Laboratorio de Investigacao Medica em Hepatologia por Virus (LIM-47), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 - Instituto de Medicina Tropical - Predio 2. Bairro Cerqueira Cesar, Sao Paulo, SP, CEP 05403-000, Brazil.
Abstract:
Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.
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