Tryptophan / Dextran70 Based - Fluorescent Silver Nanoparticles: Synthesis and Physicochemical Properties
Mariana Voicescu1, Sorana Ionescu2, Jose M Calderon-Moreno3
1Institute of Physical Chemistry "Ilie Murgulescu" of the Romanian Academy, Splaiul Independentei 202, 060021, Bucharest, Romania. voicescu@icf.ro.
Journal of Fluorescence
|July 20, 2019
Summary
Fluorescent silver nanostructures (SNPsFL) were synthesized for bio-applications. These nanoparticles show potential as markers for drug delivery and protein structure analysis in biological systems.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Materials Science
Background:
- Fluorescent silver nanostructures are crucial for drug delivery, imaging, and sensing.
- Controlling nano-size and shape is vital for optimizing bio-applications.
- Developing stable, fluorescent nanomaterials is an ongoing research area.
Purpose of the Study:
- To develop a novel fluorescent silver nano-structured system (SNPsFL).
- To synthesize SNPsFL using tryptophan and dextran 70.
- To characterize the optical and structural properties of the synthesized SNPsFL.
Main Methods:
- Chemical reduction of silver nitrate (AgNO3) using tryptophan with dextran 70 stabilization.
- Analysis using UV-Vis absorption, Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM).
- Characterization via steady-state and time-resolved fluorescence spectroscopy.
Main Results:
- TEM confirmed multi-twined nanoparticles with sizes ranging from 15-40 nm.
- SNPsFL exhibited fluorescence emission at 346 nm.
- Fluorescence quantum yield (Φ) was 0.034, and integrated fluorescence lifetime (<τ>) was 1.82 ns.
Conclusions:
- The synthesized SNPsFL are suitable for bio-applications due to their fluorescence properties.
- SNPsFL show promise as potential markers for overcoming biological barriers.
- Further studies on SNPsFL could advance drug release and protein structure analysis.
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