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Observations on the delay in onset of the acute phase protein response

M A Myers1, A Fleck

  • 1Department of Chemical Pathology, Charing Cross and Westminster Medical School, London, UK.

British Journal of Experimental Pathology
|April 1, 1988
PubMed

Insights

The acute phase protein response (APPR) involves a delay due to intermediate steps. Leucocytic endogenous mediators (LEM) shorten this delay, indicating their role in controlling the APPR.

Area of Science:

  • Biochemistry
  • Immunology
  • Physiology

Background:

  • The acute phase protein response (APPR) is a critical component of the innate immune system.
  • Understanding the kinetics and regulatory mechanisms of APPR is crucial for comprehending inflammatory processes.

Purpose of the Study:

  • To investigate the early time course of the acute phase protein response (APPR) in rats and mice.
  • To identify mediators involved in the control of the APPR.

Main Methods:

  • Turpentine-induced inflammation in rats to measure C-reactive protein and fibrinogen.
  • Endotoxin injection in mice to assess serum amyloid P-component levels.
  • Administration of leucocytic endogenous mediators (LEM) to evaluate their effect on APPR kinetics.

Main Results:

  • A significant delay (9 h in rats, 4-6 h in mice) was observed between the inflammatory stimulus and the rise in acute phase proteins.
  • Injection of LEM shortened this delay to 2 h in mice.
  • Specific acute phase proteins like C-reactive protein and fibrinogen showed distinct peak concentrations at 48 h and 18-24 h, respectively.

Conclusions:

  • The delay in APPR is attributed to obligatory intermediate steps preceding the action of final mediators.
  • Leucocytic endogenous mediators (LEM) are identified as key components that accelerate the APPR.
  • These findings elucidate the temporal dynamics and regulatory pathways of the acute phase protein response.

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