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Updated: Jan 22, 2026

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Four-Component Radical Dual Difunctionalization (RDD) of Two Different Alkenes with Aldehydes and tert-Butyl
Chuan-Shuo Wu1, Ren-Xiang Liu1, Da-You Ma2
1Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry , Xiangtan University , Hunan 411105 , P. R. China.
Abstract:
A convenient Fe-catalyzed four-component radical dual difunctionalization and ordered assembly of two alkenes with aromatic/aliphatic aldehydes and TBHP to provide chain elongated β,δ-functionalized ketones via a one-pot procedure has been developed. Aldehydes were homolytically cleavaged to produce acyl radicals and subsequently allowed for the successive construction of C(sp2)-C(sp3), C(sp3)-C(sp3), and C(sp3)-O bonds via dual radical insertions and radical-radical coupling, following the intrinsic nucleo/electrophilic reactivity of both the radicals and alkenes.
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