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Diarylpropanes from Horsfieldia kingii.
Bo Liu1,2, Ye-Gao Chen2, Xing-Jun Tian1
1School of Life Sciences, Nanjing University, Nanjing, P. R. China.
Natural Product Research
|July 20, 2019
Summary
Researchers isolated new diarylpropanes from Horsfieldia kingii. Bioactive evaluation showed these compounds were inactive against the DDC enzyme assay.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- Horsfieldia kingii is a plant species known for its potential chemical constituents.
- Diarylpropanes are a class of organic compounds with diverse biological activities.
- The DDC enzyme assay is used to evaluate potential inhibitors relevant to certain physiological processes.
Purpose of the Study:
- To isolate and characterize new diarylpropanes from Horsfieldia kingii.
- To investigate the potential bioactivity of these isolated compounds.
- To assess the inhibitory effects of new diarylpropanes on the DDC enzyme.
Main Methods:
- Extraction of plant material (twigs and leaves) using 70% aqueous acetone.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via spectroscopic analysis (e.g., NMR, MS).
- Bioactivity testing using the DDC enzyme inhibition assay.
Main Results:
- Three new diarylpropanes, including two diarylpropane glycosides, were successfully isolated.
- Three known diarylpropanes were also identified.
- The newly isolated compounds demonstrated no significant inhibitory activity in the DDC enzyme assay.
Conclusions:
- The chemical investigation of Horsfieldia kingii yielded novel diarylpropane derivatives.
- The isolated new compounds do not possess inhibitory activity against the DDC enzyme under the tested conditions.
- Further research may explore other biological activities or related compounds from this plant source.
