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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Targeted Therapy for Advanced Thyroid Cancer: Kinase Inhibitors and Beyond

Maria E Cabanillas1, Mabel Ryder2, Camilo Jimenez1

  • 1Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Endocrine Reviews
|July 20, 2019
PubMed

Insights

Advanced thyroid cancer treatment is evolving with new kinase inhibitors and mutation-specific drugs. This review covers molecular basis, available therapies, and safe administration strategies for advanced thyroid cancer.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Thyroid cancer treatment has rapidly advanced, featuring numerous kinase inhibitor approvals.
  • Several commercially available drugs are being studied for advanced thyroid cancer indications.

Purpose of the Study:

  • To review the molecular basis of thyroid cancer.
  • To discuss current and investigational drugs for advanced thyroid cancer treatment.
  • To outline safe and appropriate clinical administration of these therapies.

Main Methods:

  • Literature review of FDA-approved drugs and ongoing investigations.
  • Analysis of molecular targets and specific drug indications.
  • Discussion of safety and clinical application of advanced thyroid cancer treatments.

Main Results:

  • Most FDA-approved drugs are antiangiogenic multikinase inhibitors (e.g., vandetanib, cabozantinib).
  • Mutation-specific FDA approvals include dabrafenib/trametinib (BRAF-mutated anaplastic thyroid cancer) and larotrectinib (NTRK-fusion thyroid cancer).
  • Other targeted therapies, immunotherapies, and novel strategies are under investigation.

Conclusions:

  • Understanding thyroid cancer molecular drivers is crucial for selecting targeted therapies.
  • A growing armamentarium of drugs offers new treatment avenues for advanced thyroid cancer.
  • Personalized medicine approaches are essential for optimizing treatment outcomes in advanced thyroid cancer.

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