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Related Concept Videos

Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Jan 22, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

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Uveitis: Autoimmunity… and beyond.

Pierre-Jean Bertrand1, Yvan Jamilloux1, René Ecochard2

  • 1Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-69004 Lyon, France.

Autoimmunity Reviews
|July 20, 2019
PubMed
Summary
This summary is machine-generated.

Uveitis, an eye inflammation often linked to systemic diseases, requires a multidisciplinary approach for diagnosis. This study analyzed 912 patients, finding anterior uveitis most common and highlighting the need for early detection of underlying causes.

Keywords:
DiagnosisEpidemiologyUveitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Clinical Immunology

Background:

  • Uveitis is a frequent ophthalmological manifestation in rheumatology and immunology.
  • Approximately 60 causes of uveitis have been identified, though many cases are idiopathic.

Purpose of the Study:

  • To analyze the clinical patterns and etiologies of uveitis.
  • To investigate uveitis cases in a tertiary referral center.

Main Methods:

  • Retrospective analysis of 912 consecutive patients referred for uveitis work-up.
  • Examination of demographic, clinical, anatomical, and etiological features.

Main Results:

  • Mean age at onset was 48.8 years; 59.8% were women, 78.2% Caucasian.
  • Anterior uveitis (40.6%) was most common, followed by panuveitis (31.7%).
  • Idiopathic uveitis accounted for 46.9%; systemic diseases (37.3%) were the leading cause, including sarcoidosis (17.1%) and HLA-B27-related conditions (12.5%).

Conclusions:

  • This study presents one of the largest cohorts of uveitis patients seen in internal medicine.
  • A significant percentage of uveitis cases are associated with systemic diseases, emphasizing the need for a multidisciplinary approach to reduce diagnostic delays.